Jesse Lewis may refer to:

Jesse Lewis, American businessman, co-founder of Lewis Drug Jesse Lewis IV, American model and actor on America's Most Smartest Model , Sistas (TV series), Florida Man (TV series) Jesse Lewis, journalist, Managing Editor of The Wall Street Journal Europe Jesse Lewis (2006–2012), Sandy Hook Elementary School shooting victim; namesake of the Jesse Lewis Choose Love Movement Jesse Lewis, Japanese idol, Member of boy band SixTONES

See also Jesse Lewisohn (1872–1918), American financier Jessie Penn-Lewis (1861–1927), Welsh evangelical speaker