The United States competed at the 2011 Pan American Games in Guadalajara, Mexico, from October 14 to October 30, 2011.

The chef de mission for the United States for these Pan American Games was Alan Ashley, the USOC's Chief of Sport Performance. The city of Houston, Texas, served as the processing center for athletes participating in the 2011 Pan American Games.

Medalists Medals by sportSportTotalSwimming1819946Fencing113014Shooting104418Gymnastics95418Water skiing6017Wrestling55212Equestrian53210Athletics48517Rowing4228Bowling3104Cycling2327Archery2204Canoeing2024Water polo2002Racquetball1427Badminton1326Judo1157Tennis1124Karate1102Triathlon1102Field hockey1001Modern pentathlon1001Softball1001Sailing0426Basque pelota0213Diving0213Synchronized swimming0202Taekwondo0156Squash0134Baseball0101Table tennis0033Weightlifting0033Basketball0011Rugby sevens0011Volleyball0011Total927965236