Acquarone () is an Italian surname. Notable people with the surname include:
Lorenzo Acquarone (1931–2020), Italian politician Luciano Acquarone (1930–2024), Italian athlete Orestes Acquarone (1875–1952), Uruguayan artist Pietro Acquarone (1917–1993), Italian footballer Romeo Acquarone (1895–1980), French tennis player
See also Aquarone Pietro d'Acquarone (1890–1948), Italian soldier, entrepreneur and politician