Monolene, the deepwater lefteye flounders, is a genus of small, mainly deepwater flatfish from the Atlantic and East Pacific.

Their eyes are located on the left side of their body, and thus they have long been placed in the "lefteye flounder" family, Bothidae. However, more recent studies have split up the family into multiple families, with Monolene being identified as the sister group to the family Taeniopsettidae (formerly the subfamily Taeniopsettinae). For this reason, it was placed its own family, Monolenidae, in 2025.

Species The currently recognized species in this genus are: Monolene antillarum Norman, 1933 (slim flounder) Monolene asaedai H. W. Clark, 1936 (Asaedae flounder) Monolene atrimana Goode & T. H. Bean, 1886 (longfinned deepwater flounder) Monolene danae Bruun, 1937 Monolene dubiosa Garman, 1899 (Acapulco flounder) Monolene helenensis Amaoka & Imamura, 2000 Monolene maculipinna Garman, 1899 (Pacific deepwater flounder) Monolene megalepis Woods, 1961 Monolene mertensi (Poll, 1959) (Marten's moonflounder) Monolene microstoma Cadenat, 1937 (smallmouth moonflounder) Monolene sessilicauda Goode, 1880 (deepwater flounder)

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