ODB may refer to:
People Ol' Dirty Bastard (1968–2004), American rapper and founding member of the Wu-Tang Clan ODB (wrestler) (born 1978), Stage name of American professional wrestler Jessica Kresa Original David Baker (born 1972), a moniker of American poker player David Baker
Computers and technology .odb file extension for OpenDocument format databases Object database ODB++, a CAD-to-CAM data exchange format used in the design and manufacture of electronic devices
International relations Offense–defense balance, a theory concerning the security dilemma
Military Operational Detachment Bravo, otherwise known as 'B Team' or Special Forces Operational Detachment Bravo (SFOD B or SFOD-B), a six-man squad of the Green Berets.
Publications Our Daily Bread (devotional), Christian devotional booklets produced by Our Daily Bread Ministries Oxford Dictionary of Byzantium, a three volume historical dictionary published by Oxford University Press
Other uses ODB, the IATA airport code of Córdoba Airport