R16 may refer to:
Roads R16 road (Ghana) R-16 regional road (Montenegro)
Vehicles R16 (New York City Subway car) Lublin R-XVI, a 1932 Polish passenger and air ambulance aircraft Renault 16, a family hatchback Romano R.16, a high wing monoplane , a destroyer of the Royal Canadian Navy , an aircraft carrier of the Royal Navy , a submarine of the United States Navy
Other uses R-16 or Restricted-16, a movie rating from the Movie and Television Review and Classification Board R-16 (missile), a Soviet intercontinental ballistic missile R16 (Rodalies de Catalunya), a regional rail line in Catalonia, Spain Aika R-16: Virgin Mission, an anime OVA series R-16 Korea, an international b-boy competition R16: Explosive when mixed with oxidising substances, a risk phrase Small nucleolar RNA R16