Loizou or Loϊzou () is a Greek patronymic surname meaning "the son of Loizos". Notable people with this surname include:
Christiana Loizu (originally Loizou; born 1990), Cypriot singer Christoforos Loizou (born 1969), Cypriot footballer Giorgos Loizou (born 1990), Cypriot footballer Loizos Loizou (born 2003), Cypriot footballer Olga Loizou (born 1961), Cypriot swimmer Philipos C. Loizou (1965–2012), American professor of engineering