Threadgill is a surname. Notable people with the surname include:
Bruce Threadgill (born 1956), American football player Frances F. Threadgill (1867–1941), American women's rights activist Henry Threadgill (born 1944), American composer, saxophonist, and flautist John Threadgill (1847–1915), American politician and physician from Oklahoma Kenneth Threadgill (1909–1987), American country singer and tavern owner Pyeng Threadgill (born 1977), American blues, jazz and soul blues singer, songwriter and record producer