Manuel Peña may refer to:
Politics Juan Manuel de la Peña Bonifaz (died 1669), Spanish politician in the Philippines Manuel de la Peña y Peña (1780-1850), Mexican politician Manuel la Peña (fl 1808-1811), Spanish military officer Manuel Arturo Peña Batlle (1902-1954), Dominican politician Manuel "Lito" Peña (1924-2012), US politician
Sports Manolo Peña (1965-2012), Spanish professional footballer
Juan Manuel Peña (born 1973), Bolivian professional footballer Manuel Pena Garces (born 1983), Spanish Basketball Coach Manuel Peña López (born 1998), Argentine tennis player