Twysden or Twisden is a surname, that appears mainly in Kent, England. Notable people with the surname include:
Anne Twysden (1574–1638), English writer Philip Twysden (1713–1752), Anglican clergyman Thomas Twisden Hodges, (1809–1865) English politician Twysden baronets, two baronetcies created in the Baronetage of England, for members of the Twysden or Twisden family of Kent. Sir William Twysden, 1st Baronet (1566–1628), MP Roger Twysden (1597–1672), English historian and politician Sir Thomas Twisden, 1st Baronet, (1602–1683), English lawyer, judge and politician Sir William Twysden, 3rd Baronet (1635–1697), MP Sir Roger Twisden, 2nd Baronet, (1640–1703), English politician Sir Thomas Twisden, 3rd Baronet (1668–1728), British politician and lawyer Sir Roger Twisden, 5th Baronet (1705–1772) English Tory politician