Holles is a surname. Notable people with the surname include:
Denzil Holles, 1st Baron Holles (1599–1680), English statesman and writer, one of the "Five Members" (of Parliament) whose attempted arrest by King Charles I sparked the First English Civil War Denzil Holles, 3rd Baron Holles (1675–c. 1692), English noble and Member of Parliament (MP) Denzil Holles (MP) (c. 1538–1590) MP for East Retford Francis Holles, 2nd Baron Holles (1627–1690), English noble and MP Gervase Holles (1607–1675), English lawyer, antiquarian, and politician William Holles (1471?–1542), English merchant, Lord Mayor of London in 1539 William Holles (MP) (1510–1591), MP for Nottinghamshire