Ophidian may refer to: Ophidian, a reptile of the suborder Ophidia (or Serpentes); a snake; snake-like Ophidian (wrestler), a professional wrestler Ophidian (Dungeons & Dragons), a Dungeons & Dragons monster Ophidian 2350, a collectible card game Ophidian, a fictional hotel from the American TV show Supernatural Ophidian, a DC Comics character in stories featuring the Orange Lantern Corps