ME2 or ME-2 may refer to:
ME2 (gene) "Me²", an episode of the British sitcom Red Dwarf Mass Effect 2, a video game released for Microsoft Windows and Xbox 360 in 2010, and for PlayStation 3 in 2011 Maine's 2nd congressional district U.S. Route 2 in Maine Me1 vs Me2 Snooker with Richard Herring Me Two, French film
See also Me Too (disambiguation) MeetU, web collaboration software by PolyCom Mewtwo, a Pokémon