N-Ethylnorketamine (ethketamine, NENK, 2-Cl-2'-Oxo-PCE) is a designer drug which is presumed to have similar properties to ketamine, a dissociative anesthetic drug with hallucinogenic and sedative effects. It has been sold over the internet since around September 2012, and identified in seized drug samples by analytical laboratories in the UK and other European countries.Advisory Council on the Misuse of Drugs (ACMD) Methoxetamine Report (2012)
It is an NMDA receptor antagonist. In mice its antidepressant effects are dependent on activation of AMPA and 5-HT2 receptors, as blocking those abolishes said activity.
Legal Status
As of October 2015 NENK is a controlled substance in the United Kingdom,Explanatory Memorandum to the Misuse of Drugs (1971) Amendment Order 2013 China, and the US state of Alabama.
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