Myddelton is a surname, a variant of Middleton associated with Wales. Notable people with the surname include:
Sir Richard Myddelton, 3rd Baronet (1655–1716), Welsh politician who sat in the House of Commons from 1685 to 1705 Sir Thomas Myddelton, 1st Baronet (1624–1663), Welsh politician who sat in the House of Commons variously between 1646 and 1663 Sir Thomas Myddelton, 2nd Baronet (1651–1684), Welsh politician who sat in the House of Commons between 1679 and 1681 Robert Myddelton Biddulph (1761–1814), later Myddelton Biddulph (1761–1814), British Member of Parliament Robert Myddelton Biddulph (1805–1872) (1805–1872), British landowner and Member of Parliament for the Liberal Party Thomas Myddelton Biddulph (1809–1878), officer in the British Army and courtier Sir Humfrey Myddelton Gale KBE, CB, CVO, MC (1890–1971), officer in the British Army who served in the First and Second World War Hugh Myddelton, 1st Baronet (1560–1631), Welsh clothmaker, entrepreneur, mine-owner, goldsmith, banker and self-taught engineer Ririd Myddelton, MVO DL JP (1902–1988), country gentleman and one-time member of the Royal Household of the Sovereign of the United Kingdom Steve Myddelton (born 1986), professional Canadian football offensive lineman Thomas Myddelton (Lord Mayor of London) (1550–1631), the fourth son of Richard Myddelton, Governor of Denbigh, and Jane Dryhurst Thomas Myddelton (younger) (1586–1666), Welsh politician and Parliamentary general
See also Myddelton baronets, of Chirke in the County of Denbigh, was a title in the Baronetage of England