Šafránek (feminine Šafránková) is a Czech surname derived from the word šafrán (saffron). Notable people include: František Šafránek, Czech footballer Jaroslav Šafránek, Czech physicist Kateřina Šafránková, Czech athlete Libuše Šafránková, Czech actress Robert Safranek, American engineer Václav Šafránek, Czech tennis player Vincent Frank Safranek, Czech-American musician
See also the Hungarian fictional character Safranek.