Acedo is a surname. Notable people with the surname include:
Aquilino Acedo (1896–1964), Spanish footballer Carmen Acedo (born 1975), Spanish rhythmic gymnast Domingo Acedo (1898–1980), Spanish footballer Jérémy Acedo (born 1987), French footballer Leticia Judith Murray Acedo (born 1979), Mexican actress Manuel Aznar Acedo (1916–2001), Spanish journalist and radio personality Sara Osuna Acedo (born 1958), Spanish professor Sofía Acedo Reyes (born 1985), Spanish politician
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