The 1945 Tulane Green Wave football team was an American football that represented Tulane University as a member of the Southeastern Conference (SEC) during the 1945 college football season. In its fourth and final year under Claude Simons Jr., Tulane compiled a 2–6–1 record (1–3–1 in conference game), tied for tenth place in the SEC, and was outscored by a total of 212 to 93.

The Green Wave played its home games at Tulane Stadium in New Orleans.

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