MDE may refer to:
Education Master of Distance Education (MDE), a graduate degree offered by Athabasca University, Canada Maryland Department of Education, a state agency of Maryland, US Michigan Department of Education, a state agency of Michigan, US Minnesota Department of Education, a state agency of Minnesota, US Mississippi Department of Education, a state agency of Mississippi, US
Organizations Maryland Department of the Environment, a state agency of Maryland, US that implements and enforces environmental protection laws and programs
Science Major depressive episode Methylenedioxyethylamphetamine, a psychoactive drug Mid-domain effect spatial/area hypotheses to explain Latitudinal gradients in species diversity Methylenedioxyephedrone also known as MDE
Technology Model-driven engineering, the systematic use of models as primary engineering artifacts Multi-disciplinary Engineering, an extrapolated version of systems engineering In Microsoft Access, mde, the file extension for protected (compiled) databases Microsoft Device Emulator, an emulator for Windows Mobile-based devices Mitsubishi Design Europe, the design studio of Mitsubishi Motors Europe
Other uses Million Dollar Extreme, a comedy sketch group Maximum Downside Exposure, values the maximum downside to the portfolio Markit Document Exchange, platform used by financial market participants for distribution of account onboarding or KYC documents José María Córdova International Airport (IATA code: MDE), an airport in Colombia Major Deegan Expressway in New York City