Ababio is a Ghanaian surname. Notable people with the surname include:
(1931–2007), Ghanaian traditional ruler Alexander Ransford Ababio (1927–2002), Ghanaian politician Eddie Ababio (born 1988), Ghanaian-American soccer player Grace Amponsah-Ababio (born 1941), Ghanaian dentist and diplomat Isaac Ababio (1940–2018), Ghanaian evangelist Joyce Ababio, Ghanaian fashion designer Oblempong Nii Kojo Ababio V (1920–2017), Ghanaian dental surgeon and traditional ruler Odeneho Gyapong Ababio II, Ghanaian traditional ruler (born 1996), Dutch footballer Yaw Ntow Ababio (born 1959), Ghanaian politician
See also Gottlieb Ababio Adom (1904–1979), Ghanaian educator, journalist, editor and Presbyterian minister