451st may refer to:
451st Air Expeditionary Wing, a provisional United States Air Force Air Combat Command unit, currently in Afghanistan 451st Expeditionary Sustainment Command (ESC) is a subordinate command of 79th Sustainment Support Command 451st Flying Training Squadron, active United States Air Force unit 451st Intelligence Squadron, intelligence unit located at RAF Menwith Hill, United Kingdom
See also 451 (number) 451, the year 451 (CDLI) of the Julian calendar 451 BC