Vayne is a surname. Notable people with the surname include:
Jan Vayne (born 1966), Dutch pianist Ian Vayne (born 1962), Australian Opera Singer Kyra Vayne (1916–2001), Russian-born British opera singer
See also Vayne Solidor, the main antagonist in the video game Final Fantasy XII Shauna Vayne, the Night Hunter, a playable champion character in the multiplayer online battle arena video game League of Legends