Spyropoulos or Spiropoulos is a Greek surname. It may refer to:
Andrea Spyropoulos, British nurse Dimitris Spyropoulos, member of the Greek punk rock band Deus Ex Machina Farida Mazar Spyropoulos, birth name of Farida or Little Egypt, a Syrian belly dancer Georgia Spiropoulos (born 1965), Greek composer Jean Spiropoulos (1896–1972), Greek expert of international law Kostas Spiropoulos (born 1952), Greek painter and University Professor Nikos Spyropoulos (born 1983), Greek footballer Panagiotis Spyropoulos (born 1992), Greek footballer Theodore Spyropoulos, Greek archeologist Yiannis Spyropoulos (1912–1990), Greek painter