John Gayer or Gayre may refer to:
John Gayer (MP) (died 1571), English lawyer and MP John Gayer (Lord Mayor of London) (c. 1584–1639), English merchant, lord mayor of London in 1646 Sir John Gayer (governor of Bombay) (died 1611), English governor of Bombay for the East India Company, nephew of the above
See also John Gay (disambiguation)