Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigoid.
+ Target antigens for the different pemphigoid variants Pemphigoid variant Antibody isotype Antigen Molecular weight (KDa) Bullous pemphigoid IgG, IgE NC16A terminal of BPAG2BPAG1 180230 Gestational pemphigoid IgG1 NC16A terminal of BPAG2BPAG1 180230 Cicatricial pemphigoid C-terminal of BPAG2 180 Ocular cicatricial pemphigoid Integrin beta-4 subunit 200 Antiepiligrin cicatricial pemphigoidThe antiepiligrin variant of cicatricial pemphigoid is associated with gastric cancer. Laminin 5 (Epiligrin, Laminin 332) Linear IgA bullous dermatosis LAD1 portion of BPAG2Collagen type VII 97290/145 Protein 105 pemphigoid Protein in lower lamina lucida 105
Of note, there are also several other diseases that are caused by auto-antibodies that target the same anatomic area of the skin which is termed the basement membrane zone. These diseases include:
+ Target antigens for the different autoimmune bullous conditions targeting the basement membrane zone of the human integumentary system, excluding pemphigoid Disease Antibody isotype Antigen Molecular weight (KDa) Epidermolysis bullosa acquisita Collagen type VII 290/145 Bullous lupus erythematosus Collagen type VII 290/145 Lichen planus pemphigoidesIn this condition bullae develop on skin already affected by lesions of lichen planus as well as on areas of skin without lesions of lichen planus. BPAG2 180
Footnotes
See also List of target antigens in pemphigus List of immunofluorescence findings for autoimmune bullous conditions List of cutaneous conditions List of genes mutated in cutaneous conditions List of histologic stains that aid in diagnosis of cutaneous conditions
References