Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigus.
+ Target antigens for the different pemphigus variants Pemphigus variant Antibody isotype Antigen Molecular weight (KDa) Mucosal pemphigus vulgaris IgG Desmoglein 3 130 Mucocutaneous pemphigus vulgaris IgG Desmoglein 3Desmoglein 1 130160 Pemphigus foliaceus IgG Desmoglein 1 160 Paraneoplastic pemphigus IgG Desmoglein 3Desmoglein 1BPAG1Notably not BPAG2PlectinDesmoplakin IDesmoplakin I and II autoantibodies have also been reported in Stevens–Johnson syndromeDesmoplakin IIEnvoplakinPeriplakinAlpha-2-macroglobulin-like-1 130160230500250210210190170 Drug-induced pemphigus IgG Desmoglein 3Desmoglein 1 130160 Subcorneal pustular dermatosis type of IgA pemphigus IgA1 Desmocollin 1 110/100 Intraepidermal neutrophilic type of IgA pemphigus IgA1 Unknown Pemphigus erythematosus (Senear–Usher syndrome)Parentheticals are used to indicate other names by which a condition is known. If there are multiple alternative names for a condition, they are separated by commas within the parenthetical. IgG Desmoglein 1 160 Fogo selvagem IgG Desmoglein 1 160 Pemphigus vegetans IgG Desmoglein 3 130 Pemphigus vegetans of HallopeauPemphigus vegetans of Hallopeau represents a mild form of pemphigus vegetans. Pemphigus vegetans of Neumann represents a severe form of pemphigus vegetans. IgG Desmoglein 3 130 Pemphigus vegetans of Neumann IgG Desmoglein 3 130 Pemphigus herpetiformis IgG Desmoglein 3Desmoglein 1 130160
Footnotes
See also List of target antigens in pemphigoid List of conditions caused by problems with junctional proteins List of immunofluorescence findings for autoimmune bullous conditions List of cutaneous conditions List of genes mutated in cutaneous conditions List of histologic stains that aid in diagnosis of cutaneous conditions
References