Seneca High School is a high school in Seneca, South Carolina. It is a part of the Oconee County School District.
Notable alumni Jimmy Orr, NFL wide receiver Bennie Cunningham, NFL tight end and two-time first-team All-American Willie Aikens, MLB first baseman John Wilson, USL soccer fullback Brad Glenn, American football coach Letitia H. Verdin, South Carolina Supreme Court associate justice-elect
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