Van de Weyer or Vandeweyer is a surname. Notable people with the surname include:
André Vandeweyer (1909–1992), Belgian footballer and manager Robert Van De Weyer (born 1945), Belgian judoka Sylvain Van de Weyer (1802–1874), Belgian politician and diplomat William John Bates van de Weyer (1870–1946), British Army officer and botanist
See also Mark Vendeweyer (born 1972), Belgian sprint canoeist Weyer