The Thayer-Thompson House is an historic home that is located in Erie, Erie County, Pennsylvania, United States.

It was added to the National Register of Historic Places in 1985.

History and architectural features Completed in 1861, this historic structure is a two-story, five-bay, brick, irregularly-shaped dwelling. It is a combined Tuscan Villa/Italianate style building that features round-headed windows, prominent brackets, hipped roof with overhanging eaves, and square roof belvedere. It has an enclosed porch with Corinthian order pilasters. ()

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