Killer Joe may refer to:
Music "Killer Joe", a 1960 jazz standard composed by Benny Golson Killer Joe (Benny Golson album), 1977 Killer Joe (George Kawaguchi & Art Blakey album), 1981 Killer Joe (Jimmy Osmond album) or the title song, 1972 Killer Joe, a band formed by Australian jazz vocalist Joe Lane "Killer Joe", a 1963 song by the Rocky Fellers
Other uses Killer Joe (play), a 1993 play by Tracy Letts Killer Joe (film), a 2011 adaptation of the play, directed by William Friedkin Killer Joe Piro (1921–1989), American dance instructor