Roger Federer defeated Novak Djokovic in the final, 6–0, 7–6(9–7) to win the men's singles tennis title at the 2012 Cincinnati Masters. It was his record fifth Cincinnati Masters title, and marked the first time that a player won an ATP Masters 1000 event without having their serve broken or losing a set (a feat Federer would repeat at the 2015 event). It was Djokovic's fourth runner-up finish at the tournament.
Andy Murray was the defending champion, but lost in the third round to Jérémy Chardy.
Seeds The top eight seeds receive a bye into the second round.
Draw
Finals
Top half
Section 1
Section 2
Bottom half
Section 3
Section 4
Qualifying
Seeds
Qualifiers
Lucky losers Jérémy Chardy Alejandro Falla
Draw
First qualifier
Second qualifier
Third qualifier
Fourth qualifier
Fifth qualifier
Sixth qualifier
Seventh qualifier
References Main Draw Qualifying Draw