van Wyk is a common Afrikaans surname, derived from the Dutch Van Wijk. Notable people with the surname include:
Abraham Erasmus van Wyk (born 1952), South African taxonomist Ben-Erik van Wyk (born 1956), South African taxonomist Arnold van Wyk (1916–1983), South African composer Christopher van Wyk (1957–2014), South African writer Coenie van Wyk (born 1988), South African rugby union player D. J. Van Wyk (died 1902), a Member of the Cape House of Assembly for Riverdale Diaan van Wyk (born 1981), South African cricketer Ferdi van Wyk, (1942–2019) South African officer Hermanus van Wyk (1835–1905), Namibian tribal chief Inke van Wyk (born 1971), South African field hockey player Jandre van Wyk (born 1989), South African cricketer Janine van Wyk (born 1987), South African association football player Kruger van Wyk (born 1980), New Zealand cricketer Lenert van Wyk (born 1989), South African cricketer Morne van Wyk (born 1979), South African cricketer N. P. van Wyk Louw (1906–1970), South African poet and playwright Ruben Van Wyk (born 1976), Namibian footballer