Van Sickle is a surname. Notable people with the surname include:
Bruce Van Sickle (1917–2007), American judge Chad Van Sickle (born 1977), American boxer Clyde Van Sickle (1907–1995), American football player Frederick L. Van Sickle (born 1943), American judge Hank Van Sickle (born 1961), American musician James Hixon Van Sickle (1852–1926), American educator Neil D. Van Sickle (1915–2019), United States Air Force general Robert E. Van Sickle (born 1977), United States Army Sergeant, MMA fighter Robert L. Van Sickle (1955–2007), United States Marine Corps Sergeant
See also Van Sickle Bi-State Park, state park in California and Nevada, United States