van Schalkwyk is an Afrikaans surname. Notable people with the surname include:
Jaco van Schalkwyk (born 1979), South African rugby union player Marthinus van Schalkwyk (born 1959), South African politician Shadley van Schalkwyk (born 1988), South African cricketer Sharome van Schalkwyk, South African politician Theunis van Schalkwyk (1929–2005), South African boxer