Van Iersel is a Dutch toponymic surname meaning "from/of Iersel", a regional spelling of the town Eersel in North Brabant.Iersel, van at the Database of Surnames in The Netherlands. Variant forms are "van Ierssel," "van Iersel," "van Irsel". Notable people with the surname include:
Annita van Iersel (born 1948), Australian painter Kees van Ierssel (born 1945), Dutch football defender Ludovicus M. M. Van Iersel (1893–1987), United States Army soldier and Medal of Honor recipient Marleen van Iersel (born 1988), Dutch beach volleyball player Robin van Iersel (born 1995), Dutch biologist
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