Fritzsch is a German surname, also spelt Fritsch, Fritsche and Fritzsche, a patronymic derived from Friedrich.
Notable people with the surname include: Christian Fritzsch (1695–1769), German engraver Cladius Detlev Fritzsch (1765–1841), Danish painter Harald Fritzsch (1943–2022), German physicist Johannes Fritzsch (born 1960), German conductor Karl Fritzsch (1903–1945), German SS concentration camp commandant who was the first to use Zyklon B for mass murder Sebastian Fritzsch (born 1977), German film director, photographer and visual artist Walter Fritzsch (1920–1997), German footballer and trainer
See also Variations of the name: Fritsch Fritsche Fritzsche Frič, Czechized variation of the name