William Stapleton may refer to:
William Stapleton (died 1432), MP for Cumberland (UK Parliament constituency) William Stapleton (d. 1457) (c. 1390–1457), English regional commander William Stapleton (d. 1544) (c. 1495–1544), English politician Sir William Stapleton, 1st Baronet, Irish colonial administrator and planter Sir William Stapleton, 4th Baronet (c. 1698–1740), his son, English politician, MP for Oxfordshire William Stapleton (British Army officer) (died 1826), British general