Assefa () can be both a masculine given name and a surname. Notable people with the name include:
People with the surname Assefa Abraham Assefa, Ethiopian long-distance runner Alemseged Assefa, Ethiopian banker Alexander Assefa (born 1983), American politician Astrid Assefa, Swedish singer, actress, and theatre director Behailu Assefa (born 1989), Ethiopian football midfielder Fasil Assefa (born 1984), Ethiopian painter Fitsum Assefa, Ethiopian politician and teacher Getachew Assefa, Ethiopian politician Hizkias Assefa, Ethiopian consultant Mahder Assefa, Ethiopian actress Meskerem Assefa (born 1985), Ethiopian runner Raji Assefa, Ethiopian long-distance runner Samuel Assefa, Ethiopian academic and diplomat Sofia Assefa (born 1987), Ethiopian long-distance runner Tewodros Assefa, Ethiopian rapper Tigst Assefa (born 1994), Ethiopian long-distance runner
People with the given name Assefa Assefa Abiyo, Ethiopian politician Assefa Mezgebu (born 1978), Ethiopian long-distance runner Assefa Gebre-Mariam Tessema, Ethiopian poet and academic