Van Den Driessche or Vandendriessche is a surname. Notable people with the surname include:
Aurèle Vandendriessche (born 1932), Belgian long-distance runner Carlos Vandendriessche (1901–1972), Belgian ice hockey player and rower Femke Van den Driessche, Belgian cyclist Franky Vandendriessche (born 1971), Belgian footballer Gaston Vandendriessche (1924–2002), Belgian psychologist Johan Van den Driessche (1953–2025), Belgian politician Kévin Vandendriessche (born 1989), French footballer Kurt Vandendriessche (born 1975), Belgian actor (born 1997), Belgian volleyball player Pauline van den Driessche (born 1941), British-Canadian applied mathematician Pol Van Den Driessche, Belgian politician René Van Den Driessche (born 1928), Belgian fencer Tom Vandendriessche (born 1978), Belgian politician