Ampofo is a surname. Notable people with the surname include:
Akosua Adomako Ampofo (fl. 1989–present), Ghanaian academic Ama Ampofo (born 1991), Ghanaian actress and model Daniel Kwame Ampofo (born 1950), Ghanaian politician David Ampofo (born 1961), Ghanaian journalist Francis Ampofo (born 1967), British-Ghanaian boxer Gifty Twum-Ampofo (born 1967), Ghanaian politician Kwame Twumasi Ampofo (born 1968), Ghanaian politician Oku Ampofo (1908–1998), Ghanaian artist Owuraku Ampofo (born 1996), Ghanaian journalist Rose Akua Ampofo (1948–2003), Ghanaian educator and feminist Samuel Ofosu-Ampofo (born 1962), Ghanaian politician Bismark Ampofo (born 2002), Ghanaian professional footballer
See also
Akwasi Ampofo Adjei (1947–2004), Ghanaian musician