Agyapong or Agyepong is a Ghanaian surname that may refer to
Akosua Agyapong (born 1969), Ghanaian highlife artiste and television personality Finette Agyapong (born 1997), English sprinter Flings Owusu-Agyapong (born 1988), Ghanaian sprinter Francis Agyepong (born 1965), English triple jumper Heather Agyepong (born 1990), English actress, photographer, and visual artist Jacqui Agyepong, (born 1969), English hurdler, sister of Francis Kennedy Agyapong, Ghanaian politician and businessman Kwabena Agyapong (born 1962), Ghanaian civil engineer, politician and sports journalist Thomas Agyepong (born 1996), Ghanaian football winger