Afrifa is an Akan surname, and may refer to:
Akwasi Afrifa (1936–1979), Akan-Ghanaian brigadier, soldier, farmer, king, politician Christine Afrifa, First Lady of Ghana Elvis Afrifa (born 1997), Dutch sprinter Stephen Afrifa (born 2001), Canadian soccer player Akwasi Owusu Afrifa-Mensa (born 1971), Ghanaian politician