Opoku is an Akan given name and a surname. Notable people with the name include:
Surname Aaron Opoku-Tiawiah (or Aaron Opoku) (born 1999), German footballer Colleen Opoku Amuaben (born 1960), general superintendent Dorcas Opoku Dakwa (or Abrewa Nana) (born 1980), Ghanaian singer, songwriter and dancer Eric Opoku-Agyemang (or Eric Opoku) (born 1991), Ghanaian footballer Jonathan Opoku (born 1990), Dutch professional footballer Jordan Opoku (born 1983), Ghanaian footballer Joseph Opoku (born 2005), Ghanaian footballer Joshua Drew Opoku Okoampa (or Joshua Okoampa) (born 1984), American soccer player Joshua Otto Opoku (or Joshua Otto) (born 1990), Ghanaian footballer Kwame Opoku (born 1999), Ghanaian footballer Naana Jane Opoku-Agyemang (born 1951), Ghanaian academic Nana Opoku Agyemang-Prempeh (or Agyemang Opoku) (born 1989), Ghanaian footballer Prince Opoku Bismark Polley Sampene (or Prince Polley) (born 1969), Ghanaian footballer Samuel Opoku Nti, known as Opoku Nti (born 1961), Ghanaian footballer Sonia Opoku, Ghanaian footballer Stanley Opoku Aborah (or Stanley Aborah) (born 1987), Ghanaian-Belgian professional footballer Theophilus Opoku (1842-1913), Akan Basel missionary and teacher
Given name Opoku Ware I (1700–1750), Asantehene Opoku Ware II (1919–1999), fifteenth King of the Empire of Ashanti Opoku Afriyie, Ghanaian footballer and manager