Okyere is a surname. Notable people with the surname include:
Asante Gullit Okyere (born 1988), footballer Lawrence Adjei-Okyere (or Lawrence Adjei) (born 1979), footballer Edward Yaw Okyere Asafu-Adjaye (or Ed Asafu-Adjaye) (born 1988), footballer Nana Kwaku Okyere Duah known as Tic Tac (musician), hiplife musician Simon Okyere, Lawyer Emmanuel Kwadwo Okyere Darko, Top Security Agent Kofi Okyere Darko, Journalist Nana Yaw Okyere, Blogger