Kwakye is a name. Notable people with the name include:
Given name
Kwakye Addo (born 1951), Ghanaian politician Kwakye Darfour (born 1957), Ghanaian politician
Middle name
Felix Kwakye Ofosu ( 2018–19), Ghanaian politician Kwabena Kwakye Anti (born 1923), Ghanaian lecturer and politician
Surname
Benjamin Kwakye (born 1967), Ghanaian novelist and lawyer Benjamin Samuel Kofi Kwakye ( 1978–79), Ghanaian police official Isaac Kwakye (born 1977), Ghanaian footballer Jeanette Kwakye (born 1983), English sprinter and sports broadcaster
Other
Jacob Kwakye-Maafo (born 1940), Ghanaian physician Peter Yaw Kwakye-Ackah (born 1957), Ghanaian politician