Amponsah is a surname. Notable people with the surname include:
Koffi Amponsah (born 1978), Ghanaian footballer Reginald Reynolds Amponsah (1919–2009) Ghanaian potter and politician Daniel Amponsah known as Koo Nimo (born 1934), Ghanaian folk musician Kwame Amponsah Karikari (or Kwame Karikari) (born 1992), Ghanaian footballer Ophelia Serwaa Amponsah, Ghanaian footballer