Opare is a surname. Notable people with the surname include:
Daniel Opare (born 1990), Ghanaian footballer Frederick Opare-Ansah (born 1968), Ghanaian electrical engineer and politician Frema Opare (born 1947), Ghanaian academic, economist and politician, Chief of Staff of Ghana George Opare-Addo (born 1981), Ghanaian Lawyer and politician Jessica Opare-Saforo (born 1981), Ghanaian media personality Kofi Opare (born 1990), Ghanaian footballer Kwadwo Opare-Hammond (), Ghanaian politician Magnus Opare-Asamoah (born 1948), Ghanaian politician