William Layton may refer to:
William Layton (actor), American playwright and actor William Layton (by 1514 – 1551 or 1552), MP for Lichfield William Layton (MP for Newcastle-under-Lyme), MP for Newcastle-under-Lyme (UK Parliament constituency) Bill Layton, English footballer Billy Layton, English footballer
See also William Leighton (disambiguation)