The following is a list of Hack/Slash story arcs, appearing in their original order of publication.
One-Shots/Limited Series Euthanized Vlad and Cassie must battle Bobby, a vengeful, undead slasher with the ability to control dead animals. Bobby was revealed to have been a mentally handicapped veterinary assistant accidentally murdered by the vet's fiance, who was jealous of their friendship. This issue has a 4-page origin for Cassie, whose mother's backstory as a killer and slasher are yet to be expanded upon.
Girls Gone Dead Vlad and Cassie battle Father Wrath, a slasher being controlled by a devoutly crazy Catholic schoolgirl, Laura Lochs. Father Wrath was a traveling Baptist preacher, who was murdered by his nephew when he tried to sexually assault him. The revived Wrath emerged as an evil killer.
Comic Book Carnage Vlad and Cassie must deal with a human murderer, Lloyd Sundermann with a parasitic twin, Jimmy at a comic book convention. Breaking the fourth wall of sorts, the murderer and his brother go after Steve Niles, Scottie Young, and Robert Kirkman, real-life comic book creators, and murder them for turning an "innocent" golden age hero into a brooding "modern" hero.
The Final Revenge of Evil Ernie Cassie and Vlad battle Evil Ernie, who awakens in a new reality (the Hack/Slash world) with Ernie falling in love with Cassie. After Cassie is fatally wounded, Ernie sacrifices his life to revive her, and is reborn in a new reality elsewhere.
Land of Lost Toys Cassie and Vlad battle an undead child, Ashley Guthrie, with the ability to kill people in their dreams. They find out his mother killed him (because he was a horrible child), but he was reborn in the dream plane (à la Freddy Krueger) and uses toys to murder his victims. Cassie kills Ashley, but his spirit possesses the teddy bear his mother smothered him with. Vlad's origin has a four-page spread similar to Cassie's.
Trailers Short 2–3 page "trailers" of books. So far, only "Tub Club" has been fully expanded, but one of the stories evolves out of "Girls Gone Dead" and "Comic Book Carnage", leading to "Vs Chucky". One of the trailers has Cassie and Vlad take down slasher Hibachi Devil, who reappears in "Slice Hard".
25-cent Preview "Euthanized"'s 4 page spread (Cassie's origin) is reprinted, along with a lead-in to "Slice Hard" where Vlad and Cassie are captured by a corporation.
Slice Hard Several slashers (Hibachi Devil, Acid Angel, Mortimer Strick, X-O, and Waking Man), most featured in Cassie's origin, and never actually encountered in the comic series to date, are held prisoner by a company run by Emily Christy, a former Ms. America, that wants to use the slashers to develop anti-aging remedies. If a captured Cassie agrees to help capture the slashers, the company promises to use plastic surgery on Vlad. Ashley, now in a stuffed bear body, has other ideas when it breaks in and frees the slashers, who go after the director, Cassie, and Vlad. In the process, all the slashers are defeated, but Christy uses the "slasher formula" on herself, becoming a new slasher, named Ms. America.
Vs. Chucky Cassie and Vlad take on Chucky in a story taking place after the film Seed of Chucky. Serves as a sequel to "Girls Gone Dead". Laura Lochs uses an ancient relic to body swap out of her currently burnt to a crisp remains and into the body of none other than Vlad. It then falls upon Cassie, Vlad (Now in Laura Loch's body) and Chucky to end the now near unstoppable Loch's evil plans before she can kill several of Cassie's close friends, all having been captured and used in Laura's sick game of revenge. Cassie must also deal with the unlikely and deadly partnership with Chucky, whom she knows all too well can turn and try to kill her at any given moment.
Hack/Slash vs. Halloween Man
It was announced that a crossover with webcomic Halloween Man. Chapter 1 was released online on October 15.Devil's Due Presents HACKoween!, Comics Bulletin, October 2, 2008
Entry Wound
A cosmic disturbance (caused by Mary Shelley Lovecraft battling a number of superheroes in another dimension) results in all holiday themed slashers to awaken early, prompting Cassie and Vlad to begin frantically hunting them all down. The main villain of the story is Peter Lapage (the Candlemas Murderer) a Pennsylvania centered slasher based on Groundhog Day.
The Living Corpse Annual
In the middle of the woods a pair of campers are frightened away by the Jersey Devil, who in turn is sent home by the Living Corpse. After encountering the fleeing campers Cassie and Vlad go looking for the Jersey Devil, finding it in an abandoned house and dispatching of it with surprising ease, enraging the creature's witch parent Mother Leeds. On the way back to the van Vlad runs into and briefly fights Corpse, but the two are broken up by Cassie (who is acquainted with Corpse). As Cassie and Corpse exchange pleasantries Mother Leeds attacks, wanting revenge for the death of her son (who Corpse states was actually harmless and the only thing keeping the unstable Mother Leeds in check). Producing a never ending stream of ferocious demon "children" Mother Leeds is killed when Vlad stops her spawn from exiting her body by forcibly cramming Corpse up inside her, causing the witch to explode from the pressure.
My First Maniac
A four issue miniseries, and the first Hack/Slash books to be published by Image, the series explores Cassie's teenage years, showing her life directly after the second death of her mother, and before she met Vlad. After doing some research regarding the possible existence of slashers (through urban legends), Cassie decides to leave her foster home and travels to Manchester, Iowa, where there's a legend of an undead farmer that kills those who trespass on his land. Cassie, though becoming comfortable with the local teens, soon discovers that the slasher is actually the angry spirit of a rebellious young man named "Matthew," who is now known as a slasher called "Grinface" and has help committing his murders by his killer/girlfriend Sarah (a teen Cassie befriended). In the end, Grinface turns on Sarah and is killed by Cassie, who fulfills Sarah's dying wish of destroying her body (so she wouldn't become a slasher).
The miniseries ends with Cassie sneaking up and attacking Vlad in Chicago, whom she believes to be a slasher.
A Slice of Hell
Crossover with Devil's Due Publishing character Mercy Sparx. Limited to one-thousand copies, the one-shot (released in November) was only available for purchase through Devil's Due's online store, though copies with an alternative cover were sold at Detroit Fanfare on October 30–31.
Trailers Part Two
An anthology comic released in November 2010 featuring 13 short stories drawn by various artists.
Hack/Slash vs. Bomb Queen
Hatchet/Slash A crossover with Hatchet.
The Crow/Hack/Slash A crossover with The Crow.
Ongoing series
Hack/Slash: The Series (Volume 1)
Gross Anatomy (#1) Cassie was used as bait to lure in a slasher, who captures her and tortures her by removing two of her toes in between flashbacks to Hack/Slash: Euthanized (the original one-shot). Vlad frees her and Cassie breaks down to tears at where their life has gotten her.
Shout at The Devil (#2–4) Cassie is sent to the hell dimension of Nef by a rock singer who bargained success for the ritual periodic sacrifice of virgins, and once again it is up to Vlad to save the situation, losing his virginity to be able to take Cassie back.
Love Stories (#5) Emily Cristy aka Ms. America is brought back by a group of scientists who are attempting to understand how "Revenants" (i.e., Slashers) are made. Ms. America escapes, killing one of the scientists and stealing his skin.
Cassie and Vlad take a backseat in this issue and their story involves Vlad being ill and Cassie selling her mother's wedding ring so they have enough money to stay in a motel, which will be better for his health.
Also Chris and Lisa have a side-story involving a confrontation with Lisa's ex-boyfriend Kyle (last seen in Hack/Slash: Euthanized). Afterwards, Chris and Lisa begin a (mostly physical) relationship.
Double Date (#6) A slightly tongue-in-cheek issue done in the style of Archie Comics surrounding the return of Father Wrath, who turns out not to be the original Slasher seen in Hack/Slash: Girls Gone Dead but a teenager named Samuel Lawrence. Samuel is revealed to be Father Wrath's nephew before he is killed by Vlad.
Tub Club (#7–9) Cassie and Vlad investigate a college in Massachusetts where a series of corpses have been discovered, which have been reduced to a pile of flesh. Cassie and Vlad's relationship is somewhat rocky due to the amount of time Cassie has been spending on the phone with Georgia. After Vlad is attacked, Cassie begins questioning the local students and discovers that a number of them are lesbians who are involved in a cult surrounding the mythology of Elizabeth Bathory.
After accidentally kissing one of the students, Cassie interrogates her to find out more information about the cult. Before the student, Amber, can lead her to the cult's base of operations, Cassie encounters a government team who are also investigating the situation. One of the team admits that they worked for Cassie's father, Dr. Jack Hack and tells Cassie that he knows how to find him.
Cassie, Vlad and the government team are led by Amber into the cult's underground base. They are attacked by Ms. America, who has become stronger by stealing the blood and skin of students in an attempt to regain her original beauty. After a long battle, Vlad, now more comfortable with his own deformities, impales Ms. America. Afterwards, Cassie and Vlad reconcile, though Cassie is uncertain of her feelings towards Georgia.
Little Children (#10) Following the clue given to them by the government agent at the college, Cassie and Vlad investigate a cabin in Montana in the hopes of finding information about Cassie's father: Dr. Jack Hack. They find a series of journals describing government-sponsored research performed on a group of feral children. The children were injected with a drug called "Rev-D", which theoretically will turn them into "Revenants" i.e., Slashers.
Just as Cassie and Vlad are preparing to leave with the journals, the cabin is fire-bombed by the children. Cassie and Vlad manage to escape from the burning cabin but Vlad refuses to hurt the children as it is against his moral code. Upon escaping, Cassie shoots the children, something that Vlad is not comfortable with. At the end, Cassie, in need of comfort, phones Georgia.
The Coldest Dish (#11) Cassie and Vlad hunt down Nathan, a one-eyed vigilante, who Cassie believes is a Slasher. However, he is actually hunting down the men he holds responsible for killing his wife and mutilating him. Nathan gets his revenge but dies from a gunshot wound. Between Slasher activity, Cassie attempts to track down her father using a list of government-created false identities she found in the Montana cabin, while at the same time still pondering her feelings for Georgia.
Meanwhile, "Pooch" (the demonic dog from Shout at The Devil) has come to Earth looking for Cassie. As Cassie is busy, she asks Chris to track him down. Using items of Cassie's as bait, Chris locates Pooch and the pair of them return to Chris and Lisa's.
Murder/Suicide (Hack/Slash Annual)