Tyendinaga is an alternate spelling of Thayendanegea, an eighteenth-century Mohawk chief also known as Joseph Brant.
Tyendinaga may also refer to:
Tyendinaga Mohawk Territory, a First Nations reserve on the Bay of Quinte Mohawks of the Bay of Quinte First Nation, the First Nation government that governs that reserve Tyendinaga (Mohawk) Airport, located on that reserve Tyendinaga, Ontario, a township in Ontario